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Consortium for Anthelmintic Resistance and Susceptibility Meeting (CARS)

Venue: Jury's Inn, 1 Keel Wharf, Liverpool, L3 4FN
Date: Sunday, 16 August 2015
Cost: £50 plus VAT per person (SOLD OUT)

The Consortium for Anthelmintic Resistance and Susceptibility (CARS) brings together researchers worldwide, with a focus of advancing knowledge of resistance and providing information on detection methods and treatment strategies and to assist in the development of new drugs. The primary goal of CARS is to develop molecular markers for the detection and monitoring of anthelmintic resistance in helminth parasites of livestock, companion animals and humans. Markers can be used directly in animal and human health or can be used in research to develop our understanding of the mechanisms of drug resistance and of drug action in parasites. The group aims to facilitate interactions among researchers interested in the development of markers for anthelmintic resistance.

The day aims to provide an update of developments in research into molecular markers for each of the major groups of anthelmintic drugs, identify knowledge gaps and highlight some of the recent advances.

The full program is being finalised and details will follow shortly. It will be focused around four main themes:

8:30–8:50 Arrival
8:50–9:00 Welcome (Jane Hodgkinson)
9:00–10:35 Session 1: Chair: Ray Kaplan
9:00–9:15 Benzimidazoles - Phil Skuce
9:15–9:30 Levamisole / Derquantel – TBC
9:30–9:45 Emodepside - Jurgen Krucken
9:45–10:00 PGPs - Georg von Samson-Himmelstjerna
10:00–10:15 Triclabendazole – Erin McCammick
10:15–10:35 Macrocyclic lactones and filarial nematodes: action and resistance -
Adrian Wolstenholme
10:35–11:00 Morning tea
11:00–12:30 Session 2: Chair: Jane Hodgkinson
11:00–11:20 ML resistance from markers to understanding : D. immitis to H. contortus and other nematodes – Roger Prichard
11:20–11:40 Haemonchus contortus whole genome approaches- John Gilleard
11:40–12:00 The BUG Consortium. Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasites - Eileen Devaney
12:00–12:20 Helminth genomes – James Cotton
12:20–12:30 International Drugs and Drug resistance meeting – Richard Martin and Adrian Wolstenholme
12:30–1:40 Lunch
1:40–2:45 Session 3: Chair: TBC
1:40–1:55 Detoxification enzymes and anthelmintics - Andrew Kotze
1:55–2:10 Ivermectin exposure leads to up-regulation of detoxification genes in vitro and in vivo in mice – Anne Lespine
2:10–2:30 In vivo and In vitro approaches to phenotyping parasite populations and the CARS parasite database - Dave Bartley
2:30–2:45 Microfluidic approaches and tracking methods to phenotype parasitic larvae - Richard Martin
2:45–3:15 Afternoon tea
3:15–4:50 Session 4: Key concepts in AR
Chair: Jane Hodgkinson
3:15–4:00 Break out session:
Theme 1: Anthelmintic resistance is non-reversible? – Facilitator: Jane Hodgkinson
Theme 2: Inheritance of resistance – Facilitator: John Gilleard
Theme 3: The role of refugia – Facilitator: Ray Kaplan
Theme 4: Combination therapies – Facilitator: Richard Martin
4:00–4:45 Theme Discussion
4:45 Wrap-up
Sponsors Logos Bayer: Science for a Better Life Elanco Virbac: Passionate about animal health Norbrook: The only home-grown British pharmaceutical company MSD Animal Health Merial UK Zoetis, the largest global animal health company AAC Liverpool: Where Liverpool Welcomes the World University of Liverpool AAC Liverpool: Where Liverpool Welcomes the World Moredun